If you are allergic to alprostadil (the active medication in MUSE)
If you have an abnormally formed penis or inflammation / infection of the urethra or glans of the penis
If you have been advised not to undertake sexual activity
If you have conditions that might result in long-lasting erections, such as sickle cell anemia or trait, leukemia, low blood platelet count, high red blood cell count, or tumors of the bone marrow (multiple myeloma)
If your partner is pregnant unless you use a condom barrier
More than twice in a 24-hour period
If your erection is rigid for more than 4 hours, call your doctor promptly.
Do not drive or do other hazardous activities after taking MUSE because dizziness or fainting could occur. In patients experiencing these symptoms, the symptoms have usually occurred during the beginning of treatment and within one hour of using MUSE.
Before using MUSE, tell your doctor if you have a history of fainting. The first time you use MUSE you should be in your doctor’s office so that your doctor can find the right dose for you and monitor you for symptoms indicating that your blood pressure may be too low, like lightheadedness.
If you do feel dizzy or faint after using MUSE, this may be due to the lowering of your blood pressure. Lie down immediately and raise your legs. If these symptoms persist, call your doctor promptly.
MUSE does not protect against sexually transmitted diseases or pregnancy. Partners should use adequate protective and contraceptive measures.
The most common side effects that have been seen using MUSE are aching in the penis, testicles, legs, and in the perineum (area between the penis and rectum), warmth or burning sensation in the urethra, redness of the penis due to increased blood flow and minor urethral bleeding or spotting due to improper administration.
MUSE (alprostadil) is indicated for the treatment of erectile dysfunction. Erectile dysfunction is the inability to attain or maintain an erection sufficient for sexual intercourse.