About MUSE

If pills, needles, or pumps aren’t for you—there’s MUSE.

Male sexual arousal is a complex process that involves the brain, hormones, emotions, nerves, muscles, and blood vessels. Any or all of these can contribute to erectile dysfunction (ED).

For some men with ED, a pill does the trick. Some men like pumps or injections, but you may prefer an alternative.

That’s where MUSE comes in.

MUSE is unique.

MUSE is different from other ED treatments. It’s a small medicated pellet that works locally to produce an erection.

Reasons to consider MUSE:

  • MUSE is inserted directly into the penis
  • Unlike a pill
    • MUSE does not need to be absorbed through your stomach lining and then through your body’s bloodstream
    • MUSE is not as dependent on blood flow
  • Unlike treatment with local injection, which can bruise—and even scar—the penis, MUSE does not require you to puncture the skin of your penis
  • MUSE starts working within 5 to 10 minutes and can continue working for approximately 30 to 60 minutes
  • MUSE is a treatment option for many men with ED who want to enjoy sex on a regular basis. You are limited to using MUSE 2 times within a 24-hour period.

MUSE—a possible solution to a frustrating problem.

If pills, pumps, or needles aren’t for you, ask your doctor about MUSE. He or she will help you find the dose that works for you and provide information that can be helpful to both you and your partner.

References: 1. Mayo Clinic. Erectile dysfunction. www.mayoclinic.org/diseases-conditions/erectiledysfunction/basics/causes/con-20034244?p=1. Published May 25, 2016. Accessed July 8, 2016. 2. Muse [package insert]. Somerset, NJ: Meda Pharmaceuticals Inc.; 2014. 3. WebMD. Erectile dysfunction treatment. www.webmd.com/erectile-dysfunction/guide/erectile-dysfunction-treatment. Reviewed September 12, 2015. Accessed June 29, 2016. 4. Caverject Impulse [package insert]. New York, NY: Pfizer Inc.; 2016.

More Important Safety Information

Do not use MUSE:

  • If you are allergic to alprostadil (the active medication in MUSE)
  • If you have an abnormally formed penis or inflammation / infection of the urethra or glans of the penis
  • If you have been advised not to undertake sexual activity
  • If you have conditions that might result in long-lasting erections, such as sickle cell anemia or trait, leukemia, low blood platelet count, high red blood cell count, or tumors of the bone marrow (multiple myeloma)
  • If your partner is pregnant unless you use a condom barrier
  • More than twice in a 24-hour period

If your erection is rigid for more than 4 hours, call your doctor promptly.

Do not drive or do other hazardous activities after taking MUSE because dizziness or fainting could occur. In patients experiencing these symptoms, the symptoms have usually occurred during the beginning of treatment and within one hour of using MUSE.

Before using MUSE, tell your doctor if you have a history of fainting. The first time you use MUSE you should be in your doctor’s office so that your doctor can find the right dose for you and monitor you for symptoms indicating that your blood pressure may be too low, like lightheadedness.

If you do feel dizzy or faint after using MUSE, this may be due to the lowering of your blood pressure. Lie down immediately and raise your legs. If these symptoms persist, call your doctor promptly.

MUSE does not protect against sexually transmitted diseases or pregnancy. Partners should use adequate protective and contraceptive measures.

The most common side effects that have been seen using MUSE are aching in the penis, testicles, legs, and in the perineum (area between the penis and rectum), warmth or burning sensation in the urethra, redness of the penis due to increased blood flow and minor urethral bleeding or spotting due to improper administration.

Approved Uses

MUSE (alprostadil) is indicated for the treatment of erectile dysfunction. Erectile dysfunction is the inability to attain or maintain an erection sufficient for sexual intercourse.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

For additional information, please see the Patient Prescribing Information.