How to use MUSE

MUSE uses an applicator for delivery of a medicated pellet containing alprostadil that is gently inserted into the tip of the penis. For your convenience, each MUSE application comes in an individually wrapped foil pouch.

Follow these simple instructions for the best results.

Step 1

Immediately prior to administration, urinate and gently shake the penis several times to remove excess urine. A moist urethra makes administration of MUSE easier. The medicated pellet has been specially developed to dissolve in the small quantity of urine that remains in the urethra after urination.

Step 2

Open the foil pouch by tearing fully across, beginning from the notched edge. Let the MUSE applicator slide out of the pouch. Save the pouch for discarding the MUSE applicator later.

Step 3

To remove the protective cover from the applicator stem, hold the body of the applicator with your thumb and forefinger. Twist the body and pull out the applicator from the cover, being careful not to push in or pull out the applicator button. Avoid touching the applicator stem and tip. Save the cover for discarding the MUSE applicator later.

Step 4

Visually inspect the MUSE applicator. The MUSE system is see-through, and you will be able to see the medicated pellet at the end of the stem. Make sure that the pellet is present before insertion.

Step 5

Hold the applicator in a way that is the most comfortable for you.

Step 6

Please review the anatomy of the penis, in the figure at right.

While sitting or standing, whichever is more comfortable for you, take several seconds to gently and slowly stretch the penis upward to its full length, with gentle compression from top to bottom of the glans. This straightens and opens the urethra.

Slowly insert the MUSE applicator stem into the urethra, up to the collar of the applicator. If you feel any discomfort or a pulling sensation, withdraw the applicator slightly and then gently reinsert.

Step 7

Gently and completely push down the button at the top of the applicator until it stops. It is important to do this to ensure that the medicated pellet is completely released. Hold the applicator in this position for 5 seconds.

Step 8

Gently rock the applicator from side to side. This will separate the medicated pellet from the applicator tip. If you apply too much pressure you may scratch the lining of the urethra, causing it to bleed.

Step 9

Remove the applicator while keeping the penis upright.

Step 10

Visually inspect the applicator tip to see that the medication is no longer in the applicator. Do not touch the stem. If you notice some residual medication in the end of the applicator, gently reinsert into the urethra and repeat steps 7, 8, and 9.

Step 11

Holding the penis upright and stretched to its full length, roll the penis firmly between your hands for at least 10 seconds. This will ensure that the medication is adequately distributed along the walls of the urethra. If you feel a burning sensation, it may help to continue to roll the penis for an additional 30 to 60 seconds, or until the burning subsides.

Step 12

Remember, each MUSE applicator is good for a single administration only. Replace the cover on the MUSE applicator, place it in the opened foil pouch, then fold the pouch and discard as normal household waste.


After you have administered MUSE, it is important to sit or, preferably, stand or walk about for 10 minutes while the erection is developing. This increases blood flow to the penis and will enhance your erection.

MUSE is available in 4 strengths

You and your doctor will determine the dose strength that you need.

If your erection cannot be maintained for the time you need to have foreplay and sexual intercourse, you may need to have your dose increased. Similarly, an erection that lasts longer than you desire may require a lower dose. Consult your doctor if you think you may need a dose adjustment.

More Important Safety Information

Do not use MUSE:

  • If you are allergic to alprostadil (the active medication in MUSE)
  • If you have an abnormally formed penis or inflammation / infection of the urethra or glans of the penis
  • If you have been advised not to undertake sexual activity
  • If you have conditions that might result in long-lasting erections, such as sickle cell anemia or trait, leukemia, low blood platelet count, high red blood cell count, or tumors of the bone marrow (multiple myeloma)
  • If your partner is pregnant unless you use a condom barrier
  • More than twice in a 24-hour period

If your erection is rigid for more than 4 hours, call your doctor promptly.

Do not drive or do other hazardous activities after taking MUSE because dizziness or fainting could occur. In patients experiencing these symptoms, the symptoms have usually occurred during the beginning of treatment and within one hour of using MUSE.

Before using MUSE, tell your doctor if you have a history of fainting. The first time you use MUSE you should be in your doctor’s office so that your doctor can find the right dose for you and monitor you for symptoms indicating that your blood pressure may be too low, like lightheadedness.

If you do feel dizzy or faint after using MUSE, this may be due to the lowering of your blood pressure. Lie down immediately and raise your legs. If these symptoms persist, call your doctor promptly.

MUSE does not protect against sexually transmitted diseases or pregnancy. Partners should use adequate protective and contraceptive measures.

The most common side effects that have been seen using MUSE are aching in the penis, testicles, legs, and in the perineum (area between the penis and rectum), warmth or burning sensation in the urethra, redness of the penis due to increased blood flow and minor urethral bleeding or spotting due to improper administration.

Approved Uses

MUSE (alprostadil) is indicated for the treatment of erectile dysfunction. Erectile dysfunction is the inability to attain or maintain an erection sufficient for sexual intercourse.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

For additional information, please see the Patient Prescribing Information.